Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection.
نویسندگان
چکیده
1. Comprehensive surveillance of civets, mice, cats, Golden Syrian hamsters, and horseshoe bats is suggested when SARS or SARS-like CoVs re-emerge in the human population in the future. 2. Rabbits and horseshoe bats are animal carriers of SARS-CoV. 3. Investigation of the genetic diversity of CoV in two bat species (Rhinolophus sinicus and Rhinolophus pearsonii) should provide insights into the direct ancestor of human SARS-CoV.
منابع مشابه
COVID-19: a hypothesis to prevent SARS-CoV-2 from entering respiratory cells
Coronaviruses (CoVs) are a group of viruses that induce infection in the respiratory and other systems in the human body. There are two coronaviruses that transmitted from animals to humans including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (1). The novel coronavirus that appeared at first in Wuhan, China, in December 2019 was named as severe acut...
متن کاملThe pivotal link between ACE2 deficiency and SARS-CoV-2 infection
Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type2 pneumocytes and macrophages), kidney, testisand brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a s...
متن کاملRetroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.
Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing the receptor angiotensin-converting enzyme 2 (ACE2). Here we show that codon optimization of the SARS-CoV S-protein gene substantially enhanced S-protein expression. We also found that two retroviru...
متن کاملAntibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS.
Infection with SARS-CoV involves not only the respiratory tract but also the gastrointestinal tract and other organ systems. Several reports have highlighted the direct infection of haematopoietic cells by SARS-CoV. It is unclear how the virus gets into immune cells that do not express the SARS-CoV receptor angiotensin I converting enzyme 2 (ACE2). Immune-mediated infections and, in particular,...
متن کاملEvolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spilled over to humans via wild mammals, entering the host cell using angiotensin-converting enzyme 2 (ACE2) as receptor through Spike (S) protein binding. While SARS-CoV-2 became fully adapted to humans and globally spread, some mammal species were infected back. The present study evaluated the potential risk of mammals...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 18 Suppl 3 شماره
صفحات -
تاریخ انتشار 2012